Neural link between obsessive-compulsive disorder and delay discounting

高木 優 (1351062)


We hypothesized that obsessive-compulsive disorder(OCD) is caused by impulsive choices in intertemporal decision problems, e.g.,maladaptive preference of immediate relief from anxiety by compulsions over a future normal life by temporarily restraining their compulsions. We determined whether we could distinguish patients with OCD from healthy controls using functional network related to delay discounting that were obtained by resting-state functional magnetic resonance imaging. First, we detected the functional networks with which we predicted an individual’s discount factor. Then using the detected network, we successfully made a high performance classifier to distinguish patients with OCD from healthy controls. Our findings suggest that OCD might exhibit altered neural organization related to delay discounting