|和田 佳子||1461204: D, 中間発表||計算システムズ生物学||金谷 重彦, 佐藤 嘉伸, MD. ALTAF-UL-AMIN, 小野 直亮|
title: Directional and reoccuring sequence change in zoonotic RNA viruses genome
abstract: Viruses have always posed significant threats to public health. But human cells don't always provide the ideal growth conditions for viruses. So some kind of directional change in genomic sequences should occur during human-to-human transmission. Ebolavirus, MERS coronavirus and influenza virus are zoonotic RNA viruses, which mutate very rapidly. We conducted time-series word counts on changes in oligonucleotide compositions for ebolavirus, MERS coronavirus and influenza viruses. Directional time-series changes in many oligonucleotides were observed in common for three geographic areas (Guinea, Liberia, Sierra Leone) in the recent West Africa Ebola outbreak, The directional changes were observed also for the recent MERS coronavirus epidemics starting in the Middle East. And common directional changes were observed for three subtypes in human influenza A viruses. For designing diagnostic RT-PCR primers and therapeutic oligonucleotidesPredicting, directional and reoccurring changes in oligonucleotide composition should become important.
language of the presentation: Japanese