Technology of Radiological Science
(National Cerebral and Cardiovascular Center Research Institute)

Research Staff

  • Prof.Takahiro Higuchi

    Prof.
    Takahiro Higuchi

  • Assoc.Prof. Kazuhiro Koshino

    Assoc.Prof.
    Kazuhiro Koshino

E-mail{ thiguchi, koshino } [at] ncvc.go.jp

Research Area

We develop image-based diagnostic tools to investigate the pathophysiology of diseases in the brain, heart and other organs (kidney, lungs, liver, pancreas etc.), using nuclear medicine and molecular imaging techniques with PET (Positron Emission Tomography), SPECT (Single Photon Emission Computed Tomography) and MRI (Magnetic Resonance Imaging).
We aim to develop advanced high performance imaging techniques/devices, new tracers and image processing programs based on computer science, to quantitatively assess physiological functions in clinical application and pre-clinical animal studies.

Clinical diagnostic imaging

Rapid and quantitative PET systems for cerebral ischemia

Quantitative and standardized SPECT imaging

MRI and data analysis for morphometry and neuroimaging

Molecular imaging for pre-clinical studies

New therapy and drug evaluation

Development of animal models of diseases

Key technology development for diagnostic imaging

Image processing: Image reconstruction, motion correction, image registration

Image analysis: Quantitative assessment of physiological functions (perfusion and metabolism, tissue viability, inflammation and receptor binding), modeling of input function for completely non-invasive imaging, morphometry on MRI images

Tracer development for physiological functions

Key Features

Our laboratory is in a national center for advanced and specialized medical care and research, with scientific researchers working in a variety of fields such as computer science, physics, medicine, pharmaceutics and chemistry. We collaborate with clinical doctors, medical equipment companies, pharmaceutical companies, and domestic and international researchers.

Functional images obtained by our rapid and quantitative PET system.

Fig.1 Functional images obtained by our rapid and quantitative PET system.



Longitudinal observation of ischemic rat using a low invasive and hybrid PET and MRI imaging system.

Fig.2 Longitudinal observation of ischemic rat using a low invasive and hybrid PET and MRI imaging system.



Imaging equipment dedicated to small animals in our laboratory.

Fig.3 Imaging equipment dedicated to small animals in our laboratory.