Computational Systems Biology
Unravelling of biological systems from the perspective of genome science
It is now expected to understand the robustness and diversity of bilogical systems by advanced technologies in genome scinece. It becomes more important to get the significant information between elements in the cell by integrating several omics data, such as genome, transcriptome, metabolome and interactome. To attain, we aim to develop new methods and contribute to the understanding of biological systems.
Biology has been significantly advanced by a reductive approach. Huge biological data set, such as more than 1,000 genome sequences, has been causing a paradigm shift into a holistic approach to understand living things as systems. Now we start to sutdy the approaches by modelling several biological systems to elucidate cullular mechanisms.
With a development of omics technologies, it becomes imperative to systematically analyze all biological components (genes, mRNA, proteins and metabolites). To attain this task, we have developed a clustering algorithm (DPClus) to extract highly connected clusters.
Transcriptome is defined as a total set of transcripts in an organism. To elucidate transcriptome networks, we study transcriptome analysis by microarray and new generation sequencers with use of BL-SOM and novel methods.
Cell consists of a couple of thounsands molecules. Of those, metabolites are mainly produced by enzymatic reactions. The objective of metabolome analysis is to comprehensively find out particular metabolites which affect the cellular networks. As metabolome analysis platform, we have developed a species-metabolite database, KNApSAcK, covered almost all reported metabolites. Now, 50,048 metabolites and 101,500 species-metabolite relationships are accumulated.
Feature of the Laboratory
Our members who have wide variety of backgrounds aim to elucidate the robustness and diversity of biological systems by chemo-, bio-informatics. You can study wide range of areas and then have a broad vision. Always, we discuss about our studies and enhance each other.
Recent Dissertations and Theses